Defining the ATPome reveals cross-optimization of metabolic pathways

Disrupted energy metabolism drives cell dysfunction and disease, but approaches to increase or preserve ATP are lacking. To generate a comprehensive metabolic map of genes and pathways that regulate cellular ATP—the ATPome—we conducted a genome-wide CRISPR interference/activation screen integrated w...

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Detalles Bibliográficos
Autores principales: Bennett, Neal K., Nguyen, Mai K., Darch, Maxwell A., Nakaoka, Hiroki J., Cousineau, Derek, ten Hoeve, Johanna, Graeber, Thomas G., Schuelke, Markus, Maltepe, Emin, Kampmann, Martin, Mendelsohn, Bryce A., Nakamura, Jean L., Nakamura, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455733/
https://www.ncbi.nlm.nih.gov/pubmed/32859923
http://dx.doi.org/10.1038/s41467-020-18084-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455733/
https://www.ncbi.nlm.nih.gov/pubmed/32859923
http://dx.doi.org/10.1038/s41467-020-18084-6

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