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Defining the ATPome reveals cross-optimization of metabolic pathways
Disrupted energy metabolism drives cell dysfunction and disease, but approaches to increase or preserve ATP are lacking. To generate a comprehensive metabolic map of genes and pathways that regulate cellular ATP—the ATPome—we conducted a genome-wide CRISPR interference/activation screen integrated w...
Autores principales: | Bennett, Neal K., Nguyen, Mai K., Darch, Maxwell A., Nakaoka, Hiroki J., Cousineau, Derek, ten Hoeve, Johanna, Graeber, Thomas G., Schuelke, Markus, Maltepe, Emin, Kampmann, Martin, Mendelsohn, Bryce A., Nakamura, Jean L., Nakamura, Ken |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455733/ https://www.ncbi.nlm.nih.gov/pubmed/32859923 http://dx.doi.org/10.1038/s41467-020-18084-6 |
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