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Safety assessment of fermented jackfruit (Artocarpus heterophyllus) pulp and leaves in Sprague‐Dawley rats

Fermented jackfruit (Artocarpus heterophyllus) extracts were produced using pure symbiotic culture of bacteria and yeast (SCOBY) under controlled fermentation process. Both female and male Sprague‐Dawley rats were orally administrated with 4,000 mg/kg of fermented jackfruit pulp and leaves extracts...

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Autores principales: Sabidi, Sarah, Koh, Soo Peng, Abd Shukor, Shazwan, Adzni Sharifudin, Shaiful, Sew, Yun Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455967/
https://www.ncbi.nlm.nih.gov/pubmed/32884717
http://dx.doi.org/10.1002/fsn3.1734
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author Sabidi, Sarah
Koh, Soo Peng
Abd Shukor, Shazwan
Adzni Sharifudin, Shaiful
Sew, Yun Shin
author_facet Sabidi, Sarah
Koh, Soo Peng
Abd Shukor, Shazwan
Adzni Sharifudin, Shaiful
Sew, Yun Shin
author_sort Sabidi, Sarah
collection PubMed
description Fermented jackfruit (Artocarpus heterophyllus) extracts were produced using pure symbiotic culture of bacteria and yeast (SCOBY) under controlled fermentation process. Both female and male Sprague‐Dawley rats were orally administrated with 4,000 mg/kg of fermented jackfruit pulp and leaves extracts for 28 consecutive days. Body weight of rats was recorded at 1‐week interval until necropsy day. There was no mortality reported along the experiment with no significant differences (p > .05) record among organ histopathology and blood biochemical parameters in treated groups when compared to control group. Interestingly, there were significant differences (p < .05) in the lower body weight gained of treated rats groups as opposed to control group, indicating the potential anti‐obesity effect of fermented jackfruit extracts. In conclusion, no toxicity symptoms were observed in 28 days oral administration toxicity study of fermented jackfruit pulp and leaves extracts in Sprague‐Dawley rats for both sexes.
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spelling pubmed-74559672020-09-02 Safety assessment of fermented jackfruit (Artocarpus heterophyllus) pulp and leaves in Sprague‐Dawley rats Sabidi, Sarah Koh, Soo Peng Abd Shukor, Shazwan Adzni Sharifudin, Shaiful Sew, Yun Shin Food Sci Nutr Original Research Fermented jackfruit (Artocarpus heterophyllus) extracts were produced using pure symbiotic culture of bacteria and yeast (SCOBY) under controlled fermentation process. Both female and male Sprague‐Dawley rats were orally administrated with 4,000 mg/kg of fermented jackfruit pulp and leaves extracts for 28 consecutive days. Body weight of rats was recorded at 1‐week interval until necropsy day. There was no mortality reported along the experiment with no significant differences (p > .05) record among organ histopathology and blood biochemical parameters in treated groups when compared to control group. Interestingly, there were significant differences (p < .05) in the lower body weight gained of treated rats groups as opposed to control group, indicating the potential anti‐obesity effect of fermented jackfruit extracts. In conclusion, no toxicity symptoms were observed in 28 days oral administration toxicity study of fermented jackfruit pulp and leaves extracts in Sprague‐Dawley rats for both sexes. John Wiley and Sons Inc. 2020-07-01 /pmc/articles/PMC7455967/ /pubmed/32884717 http://dx.doi.org/10.1002/fsn3.1734 Text en © 2020 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Sabidi, Sarah
Koh, Soo Peng
Abd Shukor, Shazwan
Adzni Sharifudin, Shaiful
Sew, Yun Shin
Safety assessment of fermented jackfruit (Artocarpus heterophyllus) pulp and leaves in Sprague‐Dawley rats
title Safety assessment of fermented jackfruit (Artocarpus heterophyllus) pulp and leaves in Sprague‐Dawley rats
title_full Safety assessment of fermented jackfruit (Artocarpus heterophyllus) pulp and leaves in Sprague‐Dawley rats
title_fullStr Safety assessment of fermented jackfruit (Artocarpus heterophyllus) pulp and leaves in Sprague‐Dawley rats
title_full_unstemmed Safety assessment of fermented jackfruit (Artocarpus heterophyllus) pulp and leaves in Sprague‐Dawley rats
title_short Safety assessment of fermented jackfruit (Artocarpus heterophyllus) pulp and leaves in Sprague‐Dawley rats
title_sort safety assessment of fermented jackfruit (artocarpus heterophyllus) pulp and leaves in sprague‐dawley rats
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455967/
https://www.ncbi.nlm.nih.gov/pubmed/32884717
http://dx.doi.org/10.1002/fsn3.1734
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