Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome

Sarecycline is a new narrow-spectrum tetracycline-class antibiotic approved for the treatment of acne vulgaris. Tetracyclines share a common four-ring naphthacene core and inhibit protein synthesis by interacting with the 70S bacterial ribosome. Sarecycline is distinguished chemically from other tet...

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Detalles Bibliográficos
Autores principales: Batool, Zahra, Lomakin, Ivan B., Polikanov, Yury S., Bunick, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456112/
https://www.ncbi.nlm.nih.gov/pubmed/32817463
http://dx.doi.org/10.1073/pnas.2008671117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456112/
https://www.ncbi.nlm.nih.gov/pubmed/32817463
http://dx.doi.org/10.1073/pnas.2008671117

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