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3D model of harlequin ichthyosis reveals inflammatory therapeutic targets
The biology of harlequin ichthyosis (HI), a devastating skin disorder caused by loss-of-function mutations in the gene ABCA12, is poorly understood, and to date, no satisfactory treatment has been developed. We sought to investigate pathomechanisms of HI that could lead to the identification of new...
Autores principales: | Enjalbert, Florence, Dewan, Priya, Caley, Matthew P., Jones, Eleri M., Morse, Mary A., Kelsell, David P., Enright, Anton J., O’Toole, Edel A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456239/ https://www.ncbi.nlm.nih.gov/pubmed/32544098 http://dx.doi.org/10.1172/JCI132987 |
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