Cargando…

Squalene synthase promotes the invasion of lung cancer cells via the osteopontin/ERK pathway

Cholesterol is the major component of lipid rafts. Squalene synthase (SQS) is a cholesterol biosynthase that functions in cholesterol biosynthesis, modulates the formation of lipids rafts and promotes lung cancer metastasis. In this study, we investigated the lipid raft-associated pathway of SQS in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yi-Fang, Chang, Yu-Chan, Jan, Yi-Hua, Yang, Chih-Jen, Huang, Ming-Shyan, Hsiao, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456423/ https://www.ncbi.nlm.nih.gov/pubmed/32862200 http://dx.doi.org/10.1038/s41389-020-00262-2

Ejemplares similares

Functional characterization of squalene synthase and squalene epoxidase in Taraxacum koksaghyz
por: Unland, Kristina, et al.
Publicado: (2018)

Production of Squalene in Bacillus subtilis by Squalene Synthase Screening and Metabolic Engineering
por: Song, Yafeng, et al.
Publicado: (2020)

Accumulation of Squalene in a Microalga Chlamydomonas reinhardtii by Genetic Modification of Squalene Synthase and Squalene Epoxidase Genes
por: Kajikawa, Masataka, et al.
Publicado: (2015)

Squalene Synthase As a Target for Chagas Disease Therapeutics
por: Shang, Na, et al.
Publicado: (2014)

Positive Selection of Squalene Synthase in Cucurbitaceae Plants
por: Qian, Jieying, et al.
Publicado: (2019)

Squalene synthase predicts poor prognosis in stage I‐III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression
por: Jiang, Huihong, et al.
Publicado: (2022)

Cloning and characterization of squalene synthase and cycloartenol synthase from Siraitia grosvenorii
por: Zhao, Huan, et al.
Publicado: (2017)

A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma
por: Jan, Yi-Hua, et al.
Publicado: (2019)

Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression
por: Park, Sung Chul, et al.
Publicado: (2023)

Correction: Squalene Synthase As a Target for Chagas Disease Therapeutics
Publicado: (2014)

Transcriptional modulation of squalene synthase genes in barley treated with PGPR
por: Yousaf, Anam, et al.
Publicado: (2015)

Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule
por: Placido, Dante, et al.
Publicado: (2022)

Introduction of a green algal squalene synthase enhances squalene accumulation in a strain of Synechocystis sp. PCC 6803
por: Pattanaik, Bagmi, et al.
Publicado: (2020)

Overexpression of BZW1 is an independent poor prognosis marker and its down-regulation suppresses lung adenocarcinoma metastasis
por: Chiou, Jean, et al.
Publicado: (2019)

The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I
por: Su, Chia-Yi, et al.
Publicado: (2016)

Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis
por: Jan, Yi-Hua, et al.
Publicado: (2019)

In silico analysis of squalene synthase in Fabaceae family using bioinformatics tools
por: Aminfar, Zahra, et al.
Publicado: (2018)

Squalene synthase cloning and functional identification in wintersweet plant (Chimonanthus zhejiangensis)
por: Liu, Guanhua, et al.
Publicado: (2018)

Identification of non-conventional small molecule degraders and stabilizers of squalene synthase
por: Hoock, Joseph G. F., et al.
Publicado: (2023)

Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma
por: Chiou, Jean, et al.
Publicado: (2017)

RNAi-mediated disruption of squalene synthase improves drought tolerance and yield in rice
por: Manavalan, Lakshmi P., et al.
Publicado: (2012)

Squalene Cyclases and Cycloartenol Synthases from Polystichum polyblepharum and Six Allied Ferns
por: Shinozaki, Junichi, et al.
Publicado: (2018)

Overexpression of SQUALENE SYNTHASE Reduces Nicotiana benthamiana Resistance against Phytophthora infestans
por: Fu, Ke-Ke, et al.
Publicado: (2023)

The aberrant cancer metabolic gene carbohydrate sulfotransferase 11 promotes non-small cell lung cancer cell metastasis via dysregulation of ceruloplasmin and intracellular iron balance
por: Chang, Wei-Min, et al.
Publicado: (2022)

Cloning, Expression Analysis and Functional Characterization of Squalene Synthase (SQS) from Tripterygium wilfordii
por: Zhang, Bin, et al.
Publicado: (2018)

Mevalonate Kinase Deficiency and Squalene Synthase Inhibitor (TAK-475): The Balance to Extinguish the Inflammation
por: Rimondi, Erika, et al.
Publicado: (2021)

Molecular Cloning and Functional Identification of a Squalene Synthase Encoding Gene from Alfalfa (Medicago sativa L.)
por: Kang, Junmei, et al.
Publicado: (2019)

Surface Properties of Squalene/Meibum Films and NMR Confirmation of Squalene in Tears
por: Ivanova, Slavyana, et al.
Publicado: (2015)

Molecular Cloning and Functional Analysis of Squalene Synthase 2(SQS2) in Salvia miltiorrhiza Bunge
por: Rong, Qixian, et al.
Publicado: (2016)

A Structural and Bioinformatics Investigation of a Fungal Squalene Synthase and Comparisons with Other Membrane Proteins
por: Malwal, Satish R., et al.
Publicado: (2022)

Osteopontin regulates the growth and invasion of liver cancer cells via DTL
por: Liu, Zhiyong, et al.
Publicado: (2023)

A squalene synthase-like enzyme initiates production of tetraterpenoid hydrocarbons in Botryococcus braunii Race L
por: Thapa, Hem R., et al.
Publicado: (2016)

Squalene through Its Post-Squalene Metabolites Is a Modulator of Hepatic Transcriptome in Rabbits
por: Abuobeid, Roubi, et al.
Publicado: (2022)

Metabolic recycling of storage lipids promotes squalene biosynthesis in yeast
por: Son, So-Hee, et al.
Publicado: (2022)

Discovery of non-squalene triterpenes
por: Tao, Hui, et al.
Publicado: (2022)

Diffusion of Squalene in Nonaqueous Solvents
por: Kowert, Bruce A.
Publicado: (2022)

Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness
por: Chang, Yu-Chan, et al.
Publicado: (2020)

Enhancing ergosterol production in Pichia pastoris GS115 by overexpressing squalene synthase gene from Glycyrrhiza uralensis
por: LIU, Ying, et al.
Publicado: (2015)

Computational study to discover potent phytochemical inhibitors against drug target, squalene synthase from Leishmania donovani
por: Wadanambi, Padmika Madushanka, et al.
Publicado: (2021)

Structural and Molecular Characterization of Squalene Synthase Belonging to the Marine Thraustochytrid Species Aurantiochytrium limacinum Using Bioinformatics Approach
por: Vyas, Sachin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qprmhvqinp5lft8tkn24egmeej