USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis

OBJECTIVE: Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We inves...

Descripción completa

Detalles Bibliográficos
Autores principales: Costa, Lionel, Corre, Sébastien, Michel, Valérie, Le Luel, Krysten, Fernandes, Julien, Ziveri, Jason, Jouvion, Gregory, Danckaert, Anne, Mouchet, Nicolas, Da Silva Barreira, David, Torres, Javier, Camorlinga, Margarita, D'Elios, Mario Milco, Fiette, Laurence, De Reuse, Hilde, Galibert, Marie-Dominique, Touati, Eliette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Helicobacter Pylori
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456735/
https://www.ncbi.nlm.nih.gov/pubmed/31822580
http://dx.doi.org/10.1136/gutjnl-2019-318640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456735/
https://www.ncbi.nlm.nih.gov/pubmed/31822580
http://dx.doi.org/10.1136/gutjnl-2019-318640

Ejemplares similares