Trimetazidine Ameliorates Myocardial Metabolic Remodeling in Isoproterenol-Induced Rats Through Regulating Ketone Body Metabolism via Activating AMPK and PPAR α

BACKGROUND: Metabolic remodeling plays a vital role in the development of heart failure. The trimetazidine can optimize fatty acid and glucose oxidation via inhibition of long-chain 3-ketoacyl CoA thiolase in the heart. So, trimetazidine commonly used in cardiovascular therapy as a myocardial metabo...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Huihui, Ma, Zhi, Zhai, Yajun, Lv, Chao, Yuan, Peng, Zhu, Feng, Wei, Liping, Li, Qi, Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457052/
https://www.ncbi.nlm.nih.gov/pubmed/32922293
http://dx.doi.org/10.3389/fphar.2020.01255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457052/
https://www.ncbi.nlm.nih.gov/pubmed/32922293
http://dx.doi.org/10.3389/fphar.2020.01255

Ejemplares similares