Topical nanoparticles interfering with the DNA-LL37 complex to alleviate psoriatic inflammation in mice and monkeys

Cell-free DNA (cfDNA) released from damaged or dead cells combines with LL37 and is converted into an immune response activator to exacerbate psoriasis. Here, we show that cationic nanoparticles (cNPs) efficiently compete for DNA from the DNA-LL37 immunocomplex and inhibit DNA-LL37-induced cell acti...

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Detalles Bibliográficos
Autores principales: Liang, Huiyi, Yan, Yanzi, Wu, Jingjiao, Ge, Xiaofei, Wei, Lai, Liu, Lixin, Chen, Yongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457336/
https://www.ncbi.nlm.nih.gov/pubmed/32923608
http://dx.doi.org/10.1126/sciadv.abb5274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457336/
https://www.ncbi.nlm.nih.gov/pubmed/32923608
http://dx.doi.org/10.1126/sciadv.abb5274

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