A single molecular descriptor to predict solution behavior of therapeutic antibodies

Despite the therapeutic success of monoclonal antibodies (mAbs), early identification of developable mAb drug candidates with optimal manufacturability, stability, and delivery attributes remains elusive. Poor solution behavior, which manifests as high solution viscosity or opalescence, profoundly a...

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Detalles Bibliográficos
Autores principales: Kingsbury, Jonathan S., Saini, Amandeep, Auclair, Sarah Marie, Fu, Li, Lantz, Michaela M., Halloran, Kevin T., Calero-Rubio, Cesar, Schwenger, Walter, Airiau, Christian Y., Zhang, Jifeng, Gokarn, Yatin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457339/
https://www.ncbi.nlm.nih.gov/pubmed/32923611
http://dx.doi.org/10.1126/sciadv.abb0372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457339/
https://www.ncbi.nlm.nih.gov/pubmed/32923611
http://dx.doi.org/10.1126/sciadv.abb0372

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