UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target

BACKGROUND: N-end rule ubiquitination pathway is known to be disrupted in many diseases, including cancer. UBR5, an E3 ubiquitin ligase, is mutated and/or overexpressed in human lung cancer cells suggesting its pathological role in cancer. METHODS: We determined expression of UBR5 protein in multipl...

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Detalles Bibliográficos
Autores principales: Saurabh, Kumar, Shah, Parag P., Doll, Mark A., Siskind, Leah J., Beverly, Levi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457484/
https://www.ncbi.nlm.nih.gov/pubmed/32867711
http://dx.doi.org/10.1186/s12885-020-07322-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457484/
https://www.ncbi.nlm.nih.gov/pubmed/32867711
http://dx.doi.org/10.1186/s12885-020-07322-1

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