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UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target
BACKGROUND: N-end rule ubiquitination pathway is known to be disrupted in many diseases, including cancer. UBR5, an E3 ubiquitin ligase, is mutated and/or overexpressed in human lung cancer cells suggesting its pathological role in cancer. METHODS: We determined expression of UBR5 protein in multipl...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457484/ https://www.ncbi.nlm.nih.gov/pubmed/32867711 http://dx.doi.org/10.1186/s12885-020-07322-1 |