The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276

BACKGROUND: The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in the expression of two key immune receptors, CD276 and PD-L1. METHODS: Proximity...

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Detalles Bibliográficos
Autores principales: Li, Ruidong, Zatloukalova, Pavlina, Muller, Petr, Gil-Mir, Maria, Kote, Sachin, Wilkinson, Simon, Kemp, Alain J., Hernychova, Lenka, Wang, Yaxin, Ball, Kathryn L., Tao, Kaixiong, Hupp, Ted, Vojtesek, Borivoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457494/
https://www.ncbi.nlm.nih.gov/pubmed/32874188
http://dx.doi.org/10.1186/s11658-020-00233-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457494/
https://www.ncbi.nlm.nih.gov/pubmed/32874188
http://dx.doi.org/10.1186/s11658-020-00233-w

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