A simplified cell-based assay to identify coronavirus 3CL protease inhibitors

We describe a mammalian cell-based assay capable of identifying coronavirus 3CL protease (3CLpro) inhibitors without requiring the use of live virus. By enabling the facile testing of compounds across a range of coronavirus 3CLpro enzymes, including the one from SARS-CoV-2, we are able to quickly id...

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Detalles Bibliográficos
Autores principales: Resnick, Samuel J., Iketani, Sho, Hong, Seo Jung, Zask, Arie, Liu, Hengrui, Kim, Sungsoo, Melore, Schuyler, Nair, Manoj S., Huang, Yaoxing, Tay, Nicholas E.S., Rovis, Tomislav, Yang, Hee Won, Stockwell, Brent R., Ho, David D., Chavez, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457602/
https://www.ncbi.nlm.nih.gov/pubmed/32869020
http://dx.doi.org/10.1101/2020.08.29.272864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457602/
https://www.ncbi.nlm.nih.gov/pubmed/32869020
http://dx.doi.org/10.1101/2020.08.29.272864

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