Structural classification of neutralizing antibodies against the SARS-CoV-2 spike receptor-binding domain suggests vaccine and therapeutic strategies

The COVID-19 pandemic presents an urgent health crisis. Human neutralizing antibodies (hNAbs) that target the host ACE2 receptor-binding domain (RBD) of the SARS-CoV-2 spike(1–5) show therapeutic promise and are being evaluated clincally(6–8). To determine structural correlates of SARS-CoV-2 neutral...

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Detalles Bibliográficos
Autores principales: Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457611/
https://www.ncbi.nlm.nih.gov/pubmed/32869026
http://dx.doi.org/10.1101/2020.08.30.273920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457611/
https://www.ncbi.nlm.nih.gov/pubmed/32869026
http://dx.doi.org/10.1101/2020.08.30.273920

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