Cargando…
Intestinal stenosis in Crohn’s disease shows a generalized upregulation of genes involved in collagen metabolism and recognition that could serve as novel anti-fibrotic drug targets
BACKGROUND AND AIMS: Crohn’s disease (CD) can be complicated by intestinal fibrosis. Pharmacological therapies against intestinal fibrosis are not available. The aim of this study was to determine whether pathways involved in collagen metabolism are upregulated in intestinal fibrosis, and to discuss...
Autores principales: | van Haaften, Wouter Tobias, Blokzijl, Tjasso, Hofker, Hendrik Sijbrand, Olinga, Peter, Dijkstra, Gerard, Bank, Ruud A., Boersema, Miriam |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457685/ https://www.ncbi.nlm.nih.gov/pubmed/32922514 http://dx.doi.org/10.1177/1756284820952578 |
Ejemplares similares
-
Macromolecular Crowding as a Tool to Screen Anti-fibrotic Drugs: The Scar-in-a-Jar System Revisited
por: Puerta Cavanzo, Nataly, et al.
Publicado: (2021) -
Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease
por: van Haaften, W. T., et al.
Publicado: (2017) -
Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts
por: Cui, Yingying, et al.
Publicado: (2020) -
The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis
por: Mia, Masum M., et al.
Publicado: (2015) -
Verteporfin ameliorates fibrotic aspects of Dupuytren’s disease nodular fibroblasts irrespective the activation state of the cells
por: Puerta Cavanzo, Nataly, et al.
Publicado: (2022)