MDM2-C Functions as an E3 Ubiquitin Ligase

BACKGROUND: Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that is over-expressed in many cancers and regulates target proteins through ubiquitination. Full-length MDM2 (MDM2-FL) is best known for targeting wild-type p53 for degradation by the proteasome, but the functions of the many splice...

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Detalles Bibliográficos
Autores principales: Kim, Jun Yeob, Lee, Rusia, Xiao, Gu, Forbes, Dominique, Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457725/
https://www.ncbi.nlm.nih.gov/pubmed/32904724
http://dx.doi.org/10.2147/CMAR.S260943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457725/
https://www.ncbi.nlm.nih.gov/pubmed/32904724
http://dx.doi.org/10.2147/CMAR.S260943

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