A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers

Salmonella has been shown to preferentially colonize solid tumors. It is known that toxicity limits the systemic administration of immunomodulatory cytokines that have a significant anticancer effect. Therefore, we tested a unique cancer treatment strategy comprised of oral delivery of Saltikva, an...

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Detalles Bibliográficos
Autores principales: Gniadek, Thomas J., Augustin, Lance, Schottel, Janet, Leonard, Arnold, Saltzman, Daniel, Greeno, Edward, Batist, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Clinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458080/
https://www.ncbi.nlm.nih.gov/pubmed/32554977
http://dx.doi.org/10.1097/CJI.0000000000000325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458080/
https://www.ncbi.nlm.nih.gov/pubmed/32554977
http://dx.doi.org/10.1097/CJI.0000000000000325

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