Single-dose mRNA therapy via biomaterial-mediated sequestration of overexpressed proteins

Nonviral mRNA delivery is an attractive therapeutic gene delivery strategy, as it achieves efficient protein overexpression in vivo and has a desirable safety profile. However, mRNA’s short cytoplasmic half-life limits its utility to therapeutic applications amenable to repeated dosing or short-term...

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Detalles Bibliográficos
Autores principales: Khalil, Andrew S., Yu, Xiaohua, Umhoefer, Jennifer M., Chamberlain, Connie S., Wildenauer, Linzie A., Diarra, Gaoussou M., Hacker, Timothy A., Murphy, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458450/
https://www.ncbi.nlm.nih.gov/pubmed/32937431
http://dx.doi.org/10.1126/sciadv.aba2422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458450/
https://www.ncbi.nlm.nih.gov/pubmed/32937431
http://dx.doi.org/10.1126/sciadv.aba2422

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