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Xenogenization of tumor cells by fusogenic exosomes in tumor microenvironment ignites and propagates antitumor immunity

Many cancer patients not responding to current immunotherapies fail to produce tumor-specific T cells for various reasons, such as a lack of recognition of cancer cells as foreign. Here, we suggest a previously unidentified method for xenogenizing (turning self to non-self) tumors by using fusogenic...

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Detalles Bibliográficos
Autores principales: Kim, Gi Beom, Nam, Gi-Hoon, Hong, Yeonsun, Woo, Jiwan, Cho, Yakdol, Kwon, Ick Chan, Yang, Yoosoo, Kim, In-San
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458456/
https://www.ncbi.nlm.nih.gov/pubmed/32937446
http://dx.doi.org/10.1126/sciadv.aaz2083