The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin

Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the Ser/Thr phosphatase calcineurin (CN). It has been shown that excessive inhibition of CN is a critical factor for Down syndrome and Alzheimer’s disease. Here, we determined RCAN1’s mode of action. Using a combination of structural,...

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Detalles Bibliográficos
Autores principales: Li, Yang, Sheftic, Sarah R., Grigoriu, Simina, Schwieters, Charles D., Page, Rebecca, Peti, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458460/
https://www.ncbi.nlm.nih.gov/pubmed/32936779
http://dx.doi.org/10.1126/sciadv.aba3681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458460/
https://www.ncbi.nlm.nih.gov/pubmed/32936779
http://dx.doi.org/10.1126/sciadv.aba3681

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