Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

Kv2.1 channels mediate cell death–enabling loss of cytosolic potassium in neurons following plasma membrane insertion at somatodendritic clusters. Overexpression of the carboxyl terminus (CT) of the cognate channel Kv2.2 is neuroprotective by disrupting Kv2.1 surface clusters. Here, we define a seve...

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Detalles Bibliográficos
Autores principales: Schulien, Anthony J., Yeh, Chung-Yang, Orange, Bailey N., Pav, Olivia J., Hopkins, Madelynn P., Moutal, Aubin, Khanna, Rajesh, Sun, Dandan, Justice, Jason A., Aizenman, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458461/
https://www.ncbi.nlm.nih.gov/pubmed/32937450
http://dx.doi.org/10.1126/sciadv.aaz8110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458461/
https://www.ncbi.nlm.nih.gov/pubmed/32937450
http://dx.doi.org/10.1126/sciadv.aaz8110

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