Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect

BACKGROUND: Hyaluronic acid (HA) is a major component of extracellular matrix (ECM) and its over expression in tumor tissues contributes to the increase of interstitial fluid pressure (IFP) and hinders the penetration of nanoparticles into solid tumors. MATERIALS AND METHODS: We here reported a tumo...

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Detalles Bibliográficos
Autores principales: Chen, Enrui, Han, Shangcong, Song, Bo, Xu, Lisa, Yuan, Haicheng, Liang, Mingtao, Sun, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458542/
https://www.ncbi.nlm.nih.gov/pubmed/32922003
http://dx.doi.org/10.2147/IJN.S257164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458542/
https://www.ncbi.nlm.nih.gov/pubmed/32922003
http://dx.doi.org/10.2147/IJN.S257164

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