Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features

The endonuclease Artemis is responsible for opening DNA hairpins during V(D)J recombination and for processing a subset of pathological DNA double-strand breaks. Artemis is an attractive target for the development of therapeutics to manage various B cell and T cell tumors, because failure to open DN...

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Detalles Bibliográficos
Autores principales: Karim, Md Fazlul, Liu, Shanshan, Laciak, Adrian R., Volk, Leah, Koszelak-Rosenblum, Mary, Lieber, Michael R., Wu, Mousheng, Curtis, Rory, Huang, Nian N., Carr, Grant, Zhu, Guangyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458816/
https://www.ncbi.nlm.nih.gov/pubmed/32576658
http://dx.doi.org/10.1074/jbc.RA120.014136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458816/
https://www.ncbi.nlm.nih.gov/pubmed/32576658
http://dx.doi.org/10.1074/jbc.RA120.014136

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