Cargando…

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features

The endonuclease Artemis is responsible for opening DNA hairpins during V(D)J recombination and for processing a subset of pathological DNA double-strand breaks. Artemis is an attractive target for the development of therapeutics to manage various B cell and T cell tumors, because failure to open DN...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karim, Md Fazlul, Liu, Shanshan, Laciak, Adrian R., Volk, Leah, Koszelak-Rosenblum, Mary, Lieber, Michael R., Wu, Mousheng, Curtis, Rory, Huang, Nian N., Carr, Grant, Zhu, Guangyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458816/ https://www.ncbi.nlm.nih.gov/pubmed/32576658 http://dx.doi.org/10.1074/jbc.RA120.014136

Ejemplares similares

Biochemical and structural studies reveal differences and commonalities among cap-snatching endonucleases from segmented negative-strand RNA viruses
por: Holm, Tobias, et al.
Publicado: (2018)

The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel
por: Ward, Stephanie J., et al.
Publicado: (2018)

The Three-dimensional Structure of Carnocyclin A Reveals That Many Circular Bacteriocins Share a Common Structural Motif
por: Martin-Visscher, Leah A., et al.
Publicado: (2009)

Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle
por: Cao, Zhenbo, et al.
Publicado: (2011)

Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4
por: Denisov, Stepan S., et al.
Publicado: (2020)

Solution Structure of the Mycobacterium tuberculosis EsxG·EsxH Complex: FUNCTIONAL IMPLICATIONS AND COMPARISONS WITH OTHER M. TUBERCULOSIS Esx FAMILY COMPLEXES
por: Ilghari, Dariush, et al.
Publicado: (2011)

Structure and Orientation of Troponin in the Thin Filament
por: Paul, Danielle M., et al.
Publicado: (2009)

Structural Basis for Coronavirus-mediated Membrane Fusion: CRYSTAL STRUCTURE OF MOUSE HEPATITIS VIRUS SPIKE PROTEIN FUSION CORE
por: Xu, Yanhui, et al.
Publicado: (2004)

The Structure of an Interdomain Complex That Regulates Talin Activity
por: Goult, Benjamin T., et al.
Publicado: (2009)

Structural Determinants of Integrin Binding to the Talin Rod
por: Gingras, Alexandre R., et al.
Publicado: (2009)

Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins
por: Patel, Saleha, et al.
Publicado: (2018)

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme
por: Carlson, Brian L., et al.
Publicado: (2008)

Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia
por: Grummitt, Charles G., et al.
Publicado: (2008)

Structural basis for the specificity of renin-mediated angiotensinogen cleavage
por: Carrell, Robin W., et al.
Publicado: (2019)

Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain
por: Peng, Guiqing, et al.
Publicado: (2012)

Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases
por: Valencia-Sánchez, Marco Igor, et al.
Publicado: (2016)

Structural Characterization of the SARS-Coronavirus Spike S Fusion Protein Core
por: Tripet, Brian, et al.
Publicado: (2004)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation
por: Steichen, Jon M., et al.
Publicado: (2012)

Structural and Mechanistic Studies of Pesticin, a Bacterial Homolog of Phage Lysozymes
por: Patzer, Silke I., et al.
Publicado: (2012)

Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2
por: Newman, Joseph A, et al.
Publicado: (2015)

Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3
por: Esposito, Diego, et al.
Publicado: (2018)

Prodomain–growth factor swapping in the structure of pro-TGF-β1
por: Zhao, Bo, et al.
Publicado: (2018)

Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation
por: Grishkovskaya, Irina, et al.
Publicado: (2017)

X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions
por: Chen, Yafang, et al.
Publicado: (2015)

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway
por: Hodson, Charlotte, et al.
Publicado: (2011)

Crystal Structure of the LG1-3 Region of the Laminin α2 Chain
por: Carafoli, Federico, et al.
Publicado: (2009)

Structure and Functional Properties of Bacillus subtilis Endospore Biogenesis Factor StoA
por: Crow, Allister, et al.
Publicado: (2009)

Mutation of Conserved Histidines Alters Tertiary Structure and Nanomechanics of Consensus Ankyrin Repeats
por: Lee, Whasil, et al.
Publicado: (2012)

Structure of Signal-regulatory Protein α: A LINK TO ANTIGEN RECEPTOR EVOLUTION
por: Hatherley, Deborah, et al.
Publicado: (2009)

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand
por: Gelinas, Amy D., et al.
Publicado: (2014)

Structure of a Conserved Golgi Complex-targeting Signal in Coronavirus Envelope Proteins
por: Li, Yan, et al.
Publicado: (2014)

Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T
por: Eckhard, Ulrich, et al.
Publicado: (2013)

Olfactomedin-1 Has a V-shaped Disulfide-linked Tetrameric Structure
por: Pronker, Matti F., et al.
Publicado: (2015)

Structural Insights into the Affinity of Cel7A Carbohydrate-binding Module for Lignin
por: Strobel, Kathryn L., et al.
Publicado: (2015)

Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ
por: Somoza, John R., et al.
Publicado: (2015)

Structure and Function of the Escherichia coli Tol-Pal Stator Protein TolR
por: Wojdyla, Justyna A., et al.
Publicado: (2015)

Protein secondary structure determines the temporal relationship between folding and disulfide formation
por: Robinson, Philip J., et al.
Publicado: (2020)

Structure of the Human 26S Proteasome: SUBUNIT RADIAL DISPLACEMENTS OPEN THE GATE INTO THE PROTEOLYTIC CORE
por: da Fonseca, Paula C. A., et al.
Publicado: (2008)

Crystal Structure of Colicin M, a Novel Phosphatase Specifically Imported by Escherichia coli>
por: Zeth, Kornelius, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_aiolg89o88bikra5cb00bajhs7