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The role of the I(T)-state in D76N β(2)-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?
The D76N variant of human β(2)-microglobulin (β(2)m) is the causative agent of a hereditary amyloid disease. Interestingly, D76N-associated amyloidosis has a distinctive pathology compared with aggregation of WT-β(2)m, which occurs in dialysis-related amyloidosis. A folding intermediate of WT-β(2)m,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458819/ https://www.ncbi.nlm.nih.gov/pubmed/32661194 http://dx.doi.org/10.1074/jbc.RA120.014901 |