Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I

BACKGROUND: M184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance and increased tenofovir disoproxil fumarate (TDF) susceptibility. Nonetheless, 3TC and FTC (collectively referred to as XTC) appear to retain modest activity against human immunodeficiency virus-1 with these mut...

Descripción completa

Detalles Bibliográficos
Autores principales: Gregson, J, Rhee, S Y, Datir, R, Pillay, D, Perno, C F, Derache, A, Shafer, R S, Gupta, R K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459140/
https://www.ncbi.nlm.nih.gov/pubmed/31774913
http://dx.doi.org/10.1093/infdis/jiz631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459140/
https://www.ncbi.nlm.nih.gov/pubmed/31774913
http://dx.doi.org/10.1093/infdis/jiz631

Ejemplares similares