Functional skeletal muscle model derived from SOD1-mutant ALS patient iPSCs recapitulates hallmarks of disease progression

Recent findings suggest a pathologic role of skeletal muscle in amyotrophic lateral sclerosis (ALS) onset and progression. However, the exact mechanism by which this occurs remains elusive due to limited human-based studies. To this end, phenotypic ALS skeletal muscle models were developed from indu...

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Detalles Bibliográficos
Autores principales: Badu-Mensah, Agnes, Guo, Xiufang, McAleer, Christopher W., Rumsey, John W., Hickman, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459299/
https://www.ncbi.nlm.nih.gov/pubmed/32868812
http://dx.doi.org/10.1038/s41598-020-70510-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459299/
https://www.ncbi.nlm.nih.gov/pubmed/32868812
http://dx.doi.org/10.1038/s41598-020-70510-3

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