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Translation of small downstream ORFs enhances translation of canonical main open reading frames

In addition to canonical open reading frames (ORFs), thousands of translated small ORFs (containing less than 100 codons) have been identified in untranslated mRNA regions (UTRs) across eukaryotes. Small ORFs in 5′ UTRs (upstream (u)ORFs) often repress translation of the canonical ORF within the sam...

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Detalles Bibliográficos
Autores principales: Wu, Qiushuang, Wright, Matthew, Gogol, Madelaine M, Bradford, William D, Zhang, Ning, Bazzini, Ariel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459409/
https://www.ncbi.nlm.nih.gov/pubmed/32744758
http://dx.doi.org/10.15252/embj.2020104763