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Tracking leukemic T‐cell transcriptional dynamics in vivo with a blood‐based reporter assay

Transcriptional dynamics of cancer cells govern cell fate decisions and are therapeutically actionable drug targets. In this study, we engineered a circulating cancer cell line that secretes a luciferase reporter to capture constitutive and circadian clock‐driven transcription dynamics over the cour...

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Detalles Bibliográficos
Autores principales: Tamayo, Alfred G., Shukor, Syukri, Burr, Alexandra, Erickson, Patrick, Parekkadan, Biju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459418/
https://www.ncbi.nlm.nih.gov/pubmed/32710494
http://dx.doi.org/10.1002/2211-5463.12940