Hypermethioninemia Leads to Fatal Bleeding and Increased Mortality in a Transgenic I278T Mouse Model of Homocystinuria

Severely elevated plasma homocysteine and methionine lead to thromboembolic events and strokes in homocystinuric (HCU) patients. Mouse models of HCU failed to exhibit prothrombotic phenotype, presumably due to lack of hypermethioninemia. We evaluated the impact of hypermethioninemia together with hy...

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Detalles Bibliográficos
Autores principales: Park, Insun, Johnson, Linda K., Cox, Allaura, Branchford, Brian R., Paola, Jorge Di, Bublil, Erez M., Majtan, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459533/
https://www.ncbi.nlm.nih.gov/pubmed/32722248
http://dx.doi.org/10.3390/biomedicines8080244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459533/
https://www.ncbi.nlm.nih.gov/pubmed/32722248
http://dx.doi.org/10.3390/biomedicines8080244

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