Astemizole Sensitizes Adrenocortical Carcinoma Cells to Doxorubicin by Inhibiting Patched Drug Efflux Activity

Adrenocortical carcinoma (ACC) presents a high risk of relapse and metastases with outcomes not improving despite extensive research and new targeted therapies. We recently showed that the Hedgehog receptor Patched is expressed in ACC, where it strongly contributes to doxorubicin efflux and treatmen...

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Detalles Bibliográficos
Autores principales: Hasanovic, Anida, Simsir, Méliné, Choveau, Frank S., Lalli, Enzo, Mus-Veteau, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460240/
https://www.ncbi.nlm.nih.gov/pubmed/32751066
http://dx.doi.org/10.3390/biomedicines8080251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460240/
https://www.ncbi.nlm.nih.gov/pubmed/32751066
http://dx.doi.org/10.3390/biomedicines8080251

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