The CMV-Specific CD8(+) T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities

Evolutionary processes govern the selection of T cell clonotypes that are optimally suited to mediate efficient antigen-specific immune responses against pathogens and tumors. While the theoretical diversity of T cell receptor (TCR) sequences is vast, the antigen-specific TCR repertoire is restricte...

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Detalles Bibliográficos
Autores principales: Schober, Kilian, Fuchs, Pim, Mir, Jonas, Hammel, Monika, Fanchi, Lorenzo, Flossdorf, Michael, Busch, Dirk H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460440/
https://www.ncbi.nlm.nih.gov/pubmed/32823573
http://dx.doi.org/10.3390/pathogens9080650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460440/
https://www.ncbi.nlm.nih.gov/pubmed/32823573
http://dx.doi.org/10.3390/pathogens9080650

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