Probing the Importance of the G-Quadruplex Grooves for the Activity of the Anti-HIV-Integrase Aptamer T30923

In this paper, we report studies concerning four variants of the G-quadruplex forming anti-HIV-integrase aptamer T30923, in which specific 2′-deoxyguanosines have been singly replaced by 8-methyl-2′-deoxyguanosine residues, with the aim to exploit the methyl group positioned in the G-quadruplex groo...

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Detalles Bibliográficos
Autores principales: Esposito, Veronica, Esposito, Francesca, Pepe, Antonietta, Gomez Monterrey, Isabel, Tramontano, Enzo, Mayol, Luciano, Virgilio, Antonella, Galeone, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460552/
https://www.ncbi.nlm.nih.gov/pubmed/32781637
http://dx.doi.org/10.3390/ijms21165637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460552/
https://www.ncbi.nlm.nih.gov/pubmed/32781637
http://dx.doi.org/10.3390/ijms21165637

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