A Foundational Study for Normal F8-Containing Mouse Models for the miRNA Regulation of Hemophilia A: Identification and Analysis of Mouse miRNAs that Downregulate the Murine F8 Gene

Hemophilia A (HA) is associated with defects in the F8 gene, encoding coagulation factor VIII (FVIII). Our previous studies show that F8-targeting micro RNAs (miRNAs), a group of small RNAs involved in gene regulation, can downregulate F8 expression causing HA in individuals with normal F8-genotypes...

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Detalles Bibliográficos
Autores principales: Jankowska, Katarzyna I., Chattopadhyay, Maitreyi, Sauna, Zuben E., Atreya, Chintamani D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460574/
https://www.ncbi.nlm.nih.gov/pubmed/32781510
http://dx.doi.org/10.3390/ijms21165621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460574/
https://www.ncbi.nlm.nih.gov/pubmed/32781510
http://dx.doi.org/10.3390/ijms21165621

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