Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR

Reduced NME1 expression in melanoma cell lines, mouse models of melanoma, and melanoma specimens in human patients is associated with increased metastatic activity. Herein, we investigate the role of NME1 in repair of double-stranded breaks (DSBs) and choice of double-strand break repair (DSBR) path...

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Detalles Bibliográficos
Autores principales: Puts, Gemma, Jarrett, Stuart, Leonard, Mary, Matsangos, Nicolette, Snyder, Devin, Wang, Ying, Vincent, Richard, Portney, Benjamin, Abbotts, Rachel, McLaughlin, Lena, Zalzman, Michal, Rassool, Feyruz, Kaetzel, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460576/
https://www.ncbi.nlm.nih.gov/pubmed/32824412
http://dx.doi.org/10.3390/ijms21165896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460576/
https://www.ncbi.nlm.nih.gov/pubmed/32824412
http://dx.doi.org/10.3390/ijms21165896

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