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P38 Regulates Kainic Acid-Induced Seizure and Neuronal Firing via Kv4.2 Phosphorylation

The subthreshold, transient A-type K(+) current is a vital regulator of the excitability of neurons throughout the brain. In mammalian hippocampal pyramidal neurons, this current is carried primarily by ion channels comprising Kv4.2 α-subunits. These channels occupy the somatodendritic domains of th...

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Detalles Bibliográficos
Autores principales: Hu, Jia-hua, Malloy, Cole, Hoffman, Dax A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460594/
https://www.ncbi.nlm.nih.gov/pubmed/32824677
http://dx.doi.org/10.3390/ijms21165921