Increase in Toxicity of Anticancer Drugs by PMTPV, a Claudin-1-Binding Peptide, Mediated via Down-Regulation of Claudin-1 in Human Lung Adenocarcinoma A549 Cells

Claudin-1 (CLDN1), a tight junctional protein, is highly expressed in lung cancer cells and may contribute to chemoresistance. A drug which decreases CLDN1 expression could be a chemosensitizer for enhancing the efficacy of anticancer drugs, but there is no such drug known. We found that PMTPV, a sh...

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Detalles Bibliográficos
Autores principales: Nasako, Haruka, Takashina, Yui, Eguchi, Hiroaki, Ito, Ayaka, Ishikawa, Yoshinobu, Matsunaga, Toshiyuki, Endo, Satoshi, Ikari, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460671/
https://www.ncbi.nlm.nih.gov/pubmed/32824620
http://dx.doi.org/10.3390/ijms21165909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460671/
https://www.ncbi.nlm.nih.gov/pubmed/32824620
http://dx.doi.org/10.3390/ijms21165909

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