Role of Adipose Tissue-Derived Autotaxin, Lysophosphatidate Signaling, and Inflammation in the Progression and Treatment of Breast Cancer

Autotaxin (ATX) is a secreted enzyme that produces lysophosphatidate (LPA), which signals through six G-protein coupled receptors, promoting tumor growth, metastasis, and survival from chemotherapy and radiotherapy. Many cancer cells produce ATX, but breast cancer cells express little ATX. In breast...

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Detalles Bibliográficos
Autores principales: Brindley, David N., Tang, Xiaoyun, Meng, Guanmin, Benesch, Matthew G. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460696/
https://www.ncbi.nlm.nih.gov/pubmed/32824846
http://dx.doi.org/10.3390/ijms21165938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460696/
https://www.ncbi.nlm.nih.gov/pubmed/32824846
http://dx.doi.org/10.3390/ijms21165938

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