Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior

PDE4 cyclic nucleotide phosphodiesterases reduce 3′, 5′ cAMP levels in the CNS and thereby regulate PKA activity and the phosphorylation of CREB, fundamental to depression, cognition, and learning and memory. The PDE4 isoform PDE4D5 interacts with the signaling proteins β-arrestin2 and RACK1, regula...

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Detalles Bibliográficos
Autores principales: Bolger, Graeme B., Smoot, Lisa High Mitchell, van Groen, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460819/
https://www.ncbi.nlm.nih.gov/pubmed/32784895
http://dx.doi.org/10.3390/ijms21165704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460819/
https://www.ncbi.nlm.nih.gov/pubmed/32784895
http://dx.doi.org/10.3390/ijms21165704

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