Structural Complexity and Plasticity of Signaling Regulation at the Melanocortin-4 Receptor

The melanocortin-4 receptor (MC4R) is a class A G protein-coupled receptor (GPCR), essential for regulation of appetite and metabolism. Pathogenic inactivating MC4R mutations are the most frequent cause of monogenic obesity, a growing medical and socioeconomic problem worldwide. The MC4R mediates ei...

Descripción completa

Detalles Bibliográficos
Autores principales: Kleinau, Gunnar, Heyder, Nicolas A., Tao, Ya-Xiong, Scheerer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460885/
https://www.ncbi.nlm.nih.gov/pubmed/32785054
http://dx.doi.org/10.3390/ijms21165728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460885/
https://www.ncbi.nlm.nih.gov/pubmed/32785054
http://dx.doi.org/10.3390/ijms21165728

Ejemplares similares