Capsaicin-Cyclodextrin Complex Enhances Mepivacaine Targeting and Improves Local Anesthesia in Inflamed Tissues

Acidic environments, such as in inflamed tissues, favor the charged form of local anesthetics (LA). Hence, these drugs show less cell permeation and diminished potency. Since the analgesic capsaicin (CAP) triggers opening of the TRPV1 receptor pore, its combination with LAs could result in better up...

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Detalles Bibliográficos
Autores principales: Couto, Verônica Muniz, de Oliveira-Nascimento, Laura, Cabeça, Luiz Fernando, Geraldes, Danilo Costa, Costa, Juliana Souza Ribeiro, Riske, Karin A., Franz-Montan, Michelle, Yokaychiya, Fabiano, Franco, Margareth K. K. Dias, de Paula, Eneida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460887/
https://www.ncbi.nlm.nih.gov/pubmed/32785200
http://dx.doi.org/10.3390/ijms21165741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460887/
https://www.ncbi.nlm.nih.gov/pubmed/32785200
http://dx.doi.org/10.3390/ijms21165741

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