Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage—Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities

Philadelphia chromosome (Ph) results from a translocation between the breakpoint cluster region (BCR) gene on chromosome 9 and ABL proto-oncogene 1 (ABL1) gene on chromosome 22. The fusion gene, BCR-ABL1, is a constitutively active tyrosine kinase which promotes development of leukemia. Depending on...

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Detalles Bibliográficos
Autores principales: Komorowski, Lukasz, Fidyt, Klaudyna, Patkowska, Elżbieta, Firczuk, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460962/
https://www.ncbi.nlm.nih.gov/pubmed/32806528
http://dx.doi.org/10.3390/ijms21165776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460962/
https://www.ncbi.nlm.nih.gov/pubmed/32806528
http://dx.doi.org/10.3390/ijms21165776

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