Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid Synthesis

Pharmacologic intervention to affect the membrane lipid homeostasis of lipid rafts is a potent therapeutic strategy for cancer. Here we showed that gallic acid (GA) caused the complex formation of inactive Ras-related C3 botulinum toxin substrate 1 (Rac1)-phospho (p)-casein kinase 2 α (CK2α) (Tyr 25...

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Detalles Bibliográficos
Autores principales: Wu, Chien-Wei, Wang, Shyang-Guang, Lee, Ching-Hsiao, Chan, Wen-Ling, Lin, Meng-Liang, Chen, Shih-Shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461551/
https://www.ncbi.nlm.nih.gov/pubmed/32823607
http://dx.doi.org/10.3390/ijms21165812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461551/
https://www.ncbi.nlm.nih.gov/pubmed/32823607
http://dx.doi.org/10.3390/ijms21165812

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