Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity

Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs). Apart from being critically involved in fibrinolysis and wound healing, emerging evidence indicates that PAI-1 plays an important role in many dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Sillen, Machteld, Weeks, Stephen D., Strelkov, Sergei V., Declerck, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461574/
https://www.ncbi.nlm.nih.gov/pubmed/32824134
http://dx.doi.org/10.3390/ijms21165859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461574/
https://www.ncbi.nlm.nih.gov/pubmed/32824134
http://dx.doi.org/10.3390/ijms21165859

Ejemplares similares