The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson’s Disease

Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson’s disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative markers of LRRK2 activation in clinical samples remain at...

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Detalles Bibliográficos
Autores principales: Rideout, Hardy J., Chartier-Harlin, Marie-Christine, Fell, Matthew J., Hirst, Warren D., Huntwork-Rodriguez, Sarah, Leyns, Cheryl E. G., Mabrouk, Omar S., Taymans, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461933/
https://www.ncbi.nlm.nih.gov/pubmed/33013290
http://dx.doi.org/10.3389/fnins.2020.00865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461933/
https://www.ncbi.nlm.nih.gov/pubmed/33013290
http://dx.doi.org/10.3389/fnins.2020.00865

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