Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity

BACKGROUND: Although adoptive transfer of CD19-directed chimeric antigen receptor (CAR) T-cells (CD19-CAR T-cells) achieves high rates of complete response in patients with B-cell acute lymphoblastic leukemia (B-ALL), relapse is common. Bone marrow (BM) mesenchymal stem/stromal cells (BM-MSC) are ke...

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Detalles Bibliográficos
Autores principales: Zanetti, Samanta Romina, Romecin, Paola Alejandra, Vinyoles, Meritxell, Juan, Manel, Fuster, José Luis, Cámos, Mireia, Querol, Sergi, Delgado, Mario, Menendez, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462245/
https://www.ncbi.nlm.nih.gov/pubmed/32868394
http://dx.doi.org/10.1136/jitc-2020-001419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462245/
https://www.ncbi.nlm.nih.gov/pubmed/32868394
http://dx.doi.org/10.1136/jitc-2020-001419

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