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Sterol 14-α-demethylase is vital for mitochondrial functions and stress tolerance in Leishmania major
Sterol 14-α-demethylase (C14DM) is a key enzyme in the biosynthesis of sterols and the primary target of azoles. In Leishmania major, genetic or chemical inactivation of C14DM leads to accumulation of 14-methylated sterol intermediates and profound plasma membrane abnormalities including increased f...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462297/ https://www.ncbi.nlm.nih.gov/pubmed/32817704 http://dx.doi.org/10.1371/journal.ppat.1008810 |