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Sterol 14-α-demethylase is vital for mitochondrial functions and stress tolerance in Leishmania major

Sterol 14-α-demethylase (C14DM) is a key enzyme in the biosynthesis of sterols and the primary target of azoles. In Leishmania major, genetic or chemical inactivation of C14DM leads to accumulation of 14-methylated sterol intermediates and profound plasma membrane abnormalities including increased f...

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Detalles Bibliográficos
Autores principales:	Mukherjee, Sumit, Moitra, Samrat, Xu, Wei, Hernandez, Veronica, Zhang, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462297/ https://www.ncbi.nlm.nih.gov/pubmed/32817704 http://dx.doi.org/10.1371/journal.ppat.1008810

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