Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

Molecular-glue degraders mediate interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation. Here, we report a new molecular glue HQ461 discovered by high-throughput screening. Using loss-of-function and gain-of-function genetic scre...

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Detalles Bibliográficos
Autores principales: Lv, Lu, Chen, Peihao, Cao, Longzhi, Li, Yamei, Zeng, Zhi, Cui, Yue, Wu, Qingcui, Li, Jiaojiao, Wang, Jian-Hua, Dong, Meng-Qiu, Qi, Xiangbing, Han, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462607/
https://www.ncbi.nlm.nih.gov/pubmed/32804079
http://dx.doi.org/10.7554/eLife.59994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462607/
https://www.ncbi.nlm.nih.gov/pubmed/32804079
http://dx.doi.org/10.7554/eLife.59994

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